Publications: Biomedical Imaging


A Baboon Brain Atlas for Magnetic Resonance Imaging and Positron Emission Tomography Image Analysis.
Agaronyan A, Syed R, Kim R, Hsu CH, Love SA, Hooker JM, Reid AE, Wang PC, Ishibashi N, Kang Y, Tu TW.
Front Neuroanat. 2022 Jan; 15:778769. PMID 35095430


The oblique extraocular muscles in cetaceans: Overall architecture and accessory insertions.
Meshida K, Lin S, Domning DP, Wang P, Gilland E.
J Anat. 2021 Apr; 238(4):917-941. PMID 33131071

Comparison of in vivo and in situ detection of hippocampal metabolites in mouse brain using 1 H-MRS.
Hsu CH, Lin S, Ho AC, Johnson TD, Wang PC, Scafidi J, Tu TW.
NMR Biomed. 2021 Feb;34(2):e4451. PMID 33258202


Proton-driven transformable nanovaccine for cancer immunotherapy.
Gong N, Zhang Y, Teng X, Wang Y, Huo S, Qing G, Ni Q, Li X, Wang J, Ye X, Zhang T, Chen S, Wang Y, Yu J, Wang PC, Gan Y, Zhang J, Mitchell MJ, Li J, Liang XJ.
Nat Nanotechnol. 2020 Dec; 15(12):1053-1064. PMID 33106640

Cetacean Orbital Muscles: Anatomy and Function of the Circular Layers.
Meshida K, Lin S, Domning DP, Reidenberg JS, Wang P, Gilland E.
Anat Rec (Hoboken). 2020 Jul; 303(7):1792-1811. PMID 31587496


Sirtuin 6 Attenuates Kaposi’s Sarcoma-Associated Herpesvirus Reactivation by Suppressing Ori-Lyt Activity and Expression of RTA.
Hu M, Armstrong N, Seto E, Li W, Zhu F, Wang PC, Tang Q.
J Virol. 2019 Mar 21; 93(7):e02200-18. PMID 30651359

Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40.
Ignacio DN, Mason KD, Hackett-Morton EC, Albanese C, Ringer L, Wagner WD, Wang PC, Carducci MA, Kachhap SK, Paller CJ, Mendonca J, Li-Ying Chan L, Lin B, Hartle DK, Green JE, Brown CA, Hudson TS.
Heliyon. 2019 Jan; 5(1):e01128. PMID 30705983


Antitumor properties of Salvianolic acid B against triple-negative and hormone receptor-positive breast cancer cells via ceramide-mediated apoptosis.
Sha W, Zhou Y, Ling ZQ, Xie G, Pang X, Wang P, Gu X.
Oncotarget. 2018 Nov 20; 9(91):36331-36343. PMID 30555632

A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity.
Tan J, Li C, Wang Q, Li S, Chen S, Zhang J, Wang PC, Ren L, Liang XJ.
Mol Pharm. 2018 Apr 2;15(4):1724-1728. PMID 29522683


Through-Bond Energy Transfer Cassette with Dual-Stokes Shifts for “Double Checked” Cell Imaging.
Xue X, Jin S, Li Z, Zhang C, Guo W, Hu L, Wang PC, Zhang J, Liang XJ.
Adv Sci (Weinh). 2017 Oct 27; 4(12):1700229. PMID 29270336.

Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo.
Wen Y, Zhang W, Gong N, Wang YF, Guo HB, Guo W, Wang PC, Liang XJ.
Nanoscale. 2017 Oct 05; 9(38):14347-14356. PMID 28731112

Microstructural Alterations and Oligodendrocyte Dysmaturation in White Matter After Cardiopulmonary Bypass in a Juvenile Porcine Model.
Stinnett GR, Lin S, Korotcov AV, Korotcova L, Morton PD, Ramachandra SD, Pham A, Kumar S, Agematsu K, Zurakowski D, Wang PC, Jonas RA, Ishibashi N.
J Am Heart Assoc. 2017 Aug 15; 6(8). PMID 28862938.

Recombinant immunotoxin therapy of glioblastoma: smart design, key findings, and specific challenges.
Zhu S, Liu Y, Wang PC, Gu X, Shan L.
BioMed Res Int. 2017

MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma
Zhao Y, Ling Z, Hao Y, Pang X, Han X, Califano JA, Shan L, Gu X.
Oncotarget. 8(15):25005-25020, 2017.

Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery.
Zhang CQ, Zhang TB, Jin SB, Xue XD, Yang XL, Gong NQ, Zhang JC, Wang PC, Tian JH, Xing JF, Liang XJ.
ACS Appl Mater Interfaces (9)4425-4432, 2017

Transferrin-Dressed Virus-like Ternary Nanoparticles with Aggregation-Induced Emission for Targeted Delivery and Rapid Cytosolic Release of siRNA.
Zhang TB, Guo WS, Zhang CQ, Yu J, Xu J, Li SY, Tian JH, Wang PC, Xing JF, Liang XJ.
ACS Appl Mater Interfaces (9)16006-16014, 2017

P-gp Inhibition and Mitochondrial Impairment by Dual-Functional Nanostructure Based on Vitamin E Derivatives To Overcome Multidrug Resistance.
Tuguntaev RG, Chen SZ, Eltahan AS, Mozhi A, Jin SB, Zhang JC, Li C, Wang PC, Liang XJ.
ACS Appl Mater Interfaces (9)16900-16912, 2017

Chemical Exchange Saturation Transfer weighted MR imaging in experimental traumatic brain injury
Tu TW, Ibrahim W, Jikaria N, Munasinghe J, Witko, Hammoud D, Frank JA.
2017 (under revision)

Abnormal injury response in spontaneous mild ventriculomegaly Wistar rat brains: a diffusion tensor and magnetization transfer imaging study
Tu TW, Lescher JD, Williams RA, Jikaria N, Turtzo LC, Frank JA.
J Neurotrauma, 2017 Jan 1;34(1):248-256


Altered White Matter Anisotropy and Oligodendrocyte Dysmaturation after Congenital Heart Surgery.

Ishibashi N, Korotcov AV, Lin S, Korotcova L, Stinnett GR, Morton PD, Ramachandra SD, Kumar S, Agematsu K, Zurakowski D, Wang PC, Jonas RA.
J Am Heart Assoc. 6(8), 2017, doi: 10.1161/JAHA.117.005997. PubMed PMID: 28862938

Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines with Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy.
Lv GX, Guo WS, Zhang W, Zhang TB, Li SY, Chen SZ, Eltahan AS, Wang DL, Wang YQ,. Zhang JC, Wang PC, Chang J, Liang XJ.

ACS Nano (10)9637-9645, 2016, PMID 27623101

A Photosensitizer-Loaded DNA Origami Nanosystem for Photodynamic Therapy.
Zhuang XX, Ma XW, Xue XD, Jiang Q, Long LL, Dai LR, Zhang CQ, Jin SB, Yang KN, Ding BQ, Wang PC, Liang XJ.
ACS Nano (10)3486-3495, 2016, PMC4837698

Radiological-pathological correlation of diffusion tensor and magnetization transfer imaging in closed head mild traumatic brain injury model
Tu TW, Williams RA, Lescher JD, Jikaria N, Turtzo LC, Frank JA.
Ann Neurol. 2016 Jun;79(6):907-20


A highly potent bispecific bivalent recombinant immunotoxin against tumors with EGFR and EGFRvIII expression.
Meng J, Liu Y, Gao Y, Lin S, Gu X, Pomper M, Wang PC, Shan L.
Cancer Biol Therapy, 16(12):1764-74, 2015

The Human Brain and Face: Mechanisms of Cranial, Neurological and Facial Development Revealed Through Malformations of Holoprosencephaly, Cyclopia and Aberrations in Chromosome 18.
Gondre-Lewis M, Gboluaje T, Reid SN, Lin S, Wang P, Green W, Diogo R, Fidelia-Lambert F, Herman MM.
J. Anat (227)255-267, 2015, PMID 26278930, PMC4560560

MiRNA-128 Acts As A Tumor Suppressor by Regulating the Pathways Associated with Head and Neck Cancer Cell Growth and Apoptosis.
Hauser B, Pang XW, Ling ZG, Myers E, Wang PC, Califano J, Gu XB.

Plos One, March 12, 10(3):e011632, 2015, PMID 25764126


Non-Invasive MRI and Spectroscopy of mdx Mice Reveal Temporal Changes in Dystrophic Muscle Imaging and in Energy Deficits.
Heier CR, Guerron AD, Korotcov A, Lin S, Gordish-Dressman H, Fricke S, Sze RW, Hoffman EP, Wang P, Nagaraju K.
Plos One 9(11)e112477. Nov 12, 2014. PMID 25390038

pH-Responsive Mesoporous Silica Nanoparticles Applied in Controlled Drug Delivery Systems for Cancer Treatment.
Yang KN, Zhang CQ, Wang W, Wang PC, Zhou JP, Liang XJ.
Cancer Biol Med. 11(1):34-43, 2014. PMID 24738037

Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry.
Huo SD, Jin SB, Ma XW, Xue XD, Yang KN, Kumar A, Wang PC, Zhang JC, Hu ZB, Liang XJ.
ACS Nano 8(6):5852-5862, 2014, PMID 24824865

Eccentric Muscle Challenge Shows Osteopontin Polymorphism Modulation of Muscle Damage.
Barfield W, Uaesoontrachoon K, Wu CS, Lin S, Chen Y, Wang PC, Kanaan Y, Bond V, Hoffman EP.
Hum Mol Genet 23(15):4043-50, 2014, PMID 24626632

Biosafety Nanoscale Pharmaceutical Adjuvant Materials.
Jin SB, Li SL, Wang CX, Liu J, Yang XL, Wang PC, Zhang X, Liang XJ.
J Biomed Nanotechnol 10(9)2393-419, 2014, PMID 25429253

Techniques for Physicochemical Characterization of Nanomaterials.
Lin PC, Lin S, Wang PC, Sridhar R.
Biotechnol Adv. (4):711-726, 2014. PMID 24252561

 Imaging of spontaneous ventriculomegaly and vascular malformations in Wistar rats: Implications for preclinical research
Tu TW, Turtzo LC, Williams RA, Lescher JD, Dean DD, Frank JA.
J Neuropathol Exp Neurol. 2014, 73(12),1152-65

Phase-Aligned Multiple Spin-Echo Averaging: A Simple Way to Improve Signal-to-Noise Ratio of in vivo Mouse Spinal Cord Diffusion Tensor Image
Tu TW, MD Budde, M Xie, Y Chen Jr, Q Wang, JD Quirk, SK Song
Magn Reson Imaging. 2014, 32(10),1335-43


Recombinant immunotoxin therapy of solid tumors: challenges and strategies.
Shan L, Liu Y, Wang P.
J Basic Clin Med. 2(2):1-6, 2013

Nanoscale Drug Delivery Platforms Overcome Platinum-Based Resistance in Cancer Cells Due to Abnormal Membrane Protein Trafficking.
Xue X, Hall HD, Zhang Q, Wang PC, Gottesman MM, Liang XJ.

ACS Nano vol.7 (12)10452-10464, 2013. PMID 24219825

An anti-PSMA bivalent immunotoxin exhibits specificity and efficacy for prostate cancer imaging and therapy.
Zhang F, Shan L, Liu Y, Neville D, Chen Y, Korotcov A, Lin S, Huang S, Sridhar R, Liang W, Wang PC.
Adv Healthc Mater. 2(5):736-44, 2013 PMID 23184611.

The impact of myelination on axon sparing and locomotor function recovery in spinal cord injury assessed using diffusion tensor imaging
Tu TW, Kim JH, Jakeman LB, Song SK.
NMR Biomed. 2013, 26 (11), 1484-1495

Assessing white matter integrity in experimental spinal cord injury using diffusion tensor imaging
Tu TW, Frank JA
J Neurosci Neuroeng. 2013, 2 (5), 415-430


Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging.
Shan, L, Chopra, A, Eckelman, WC, Leung, K, Menkens, A.

J Nanoparticle Res. 14:1122, 2012

Molecular imaging and contrast agent database (MICAD): Evolution and progress.
Chopra, A, Shan, L, Eckelman, WC, Leung, K, Latterner, M, Bryant, S, Menkens, A.

Mol Imaging Biol. 14:4-13, 2012

Single-Walled Carbon Nanotubes Alter Cytochrome C Electron Transfer and Modulate Mitochondrial Function.
Ma XW, Zhang LH, Wang LR, Xue X, Sun JH, Wu Y, Zou GZ, Wu X, Wang PC, Wamer WG, Yin JJ, Zheng KY, Liang XJ.

ACS Nano 6(12)10486-96, 2012. PMID 23171082

Evaluation of Tumor Cell Response to Hyperthermia with Bioluminescent Imaging.
Zhang RS, Zhou YF, Wang PC, Sridhar R.
J Basic and Clinical Medicine 1(1)16-19, 2012. PMID 23745173

Essential Elements to Consider for MRI Cell Tracking Studies with Iron Oxide based Labeling Agents.
Wang PC, Shan L.
J Basic and Clinical Medicine 1(1)1-6, 2012. PMID 24159426

Essential parameters to consider for the characterization of optical imaging probes.
Leung, K, Chopra, A, Shan, L, Eckelman, WC, Menkens, A.

Nanomedicine 7:1101-7, 2012

Loperamide, an FDA-approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity.
Zhou Y, Sridhar R, Shan L, Sha W, Gu X, Sukumar S.

Cancer Invest.  30:119-25, 2012

Design Principles of Nanoparticles as Contrast Agents for Magnetic Resonance Imaging.
Shan L, Gu XB, Wang PC.

Nanopharmaceutics: The Potential Application of Nanomaterials. Chapter 11, Xing-Jie Liang (ed), World Scientific Publisher, 2012

Size-Dependent Localization and Penetration of Ultrasmall Gold Nano-particles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo.
Huang KY, Ma HL, Liu J, Huo S, Kumar A, Wei T, Zhang X, Jin S, Gan Y, Wang PC, H S, Zhang X, Liang XJ.

ACS Nano 6(5)4483-4493, 2012. PMID: 22540892

Gadolinium Metallofullerenol Nanoparticle Inhibits Cancer Metastasis through Matrix Metalloproteinase Inhibition: Imprisoning Instead of Poisoning Cancer Cells.
Meng H, Xing GM, Blanco E, Song Y, Zhao L, Sun BY, Li XD, Wang PC, Korotcov A, Li W, Liang XJ, Chen CY, Yuan H, Zhao F, Chen Z, Sun T, Chai ZF, Farrari M, Zhao YL.

Nanomedicine 8(2):136-146, 2012, PMID 21930111

Glucosamine Linked Near-infrared Fluorescent Probes for Imaging of Solid Tumor Xenografts.
Korotcov AV, Ye YP, Chen Y, Zhang FY, Huang S, Lin S, Sridhar R, Achilefu S, Wang PC.

Mol Imaging Biol (14)443-451, 2012, PMID21971932, PMC3288187