Research: Proteomics
Focus Areas
- Regulation of HIV-1 transcription by host cell CDK2 and protein phosphatase-1
- Effect of iron chelators and hypoxia on activation of HIV-1 transcription
- Design of small molecule inhibitors that target phosphatase-1 and inhibit HIV-1
- Effect of abnormal hypoxic response in Sickle Cell Disease and Chuvash polycythemia in development of pulmonary hypertension
- Design small molecule PP1 inhibitors to prevent sickling of Sickle Cell Disease red blood cells
Sergei Nekhai, Ph.D.