MRI

MRI Facilities: Biomedical Imaging

The laboratory has two state-of-the-art NMR machines: a Bruker Avance III 7 Tesla (300 MHz), 21cm horizontal bore MRI/MRS system and a Bruker Avance 9.4 Tesla (400 MHz), 89 mm vertical bore MRI/MRS system. Both MRI/MRS systems are capable of performing MRI as well as spectroscopy studies. The NMR laboratory has acquisition workstations, a storage server and several workstations for spectroscopy data and image processing.

Bruker 7T MRI with researcher inserting sample into magnet
Bruker 7T MRI
  • Bruker 7 Tesla (300MHz) MRI/MRS
  • 210mm horizontal bore Magnex magnet, 112mm clear space
  • RF Coils: Volume, surface, and custom-made coils
  • AVANCE III Console, Paravision 6 (PV6) software
  • Detectable nuclei: 1H

 

Bruker 9.4T Magnet system lab space
Bruker 9.4T MRI
  • Bruker 9.4 Tesla (400MHz) MRI/MRS
  • 89mm vetical bore Oxford magnet
  • RF Coils: Volume, surface, and custom-made coils
  • AVANCE 400 Console, Paravision 5.1 (PV5) software
  • Detectable nuclei: 1H, 19F, 13C, 31P

 

Sample MRI Images

MRI images of heart, kidneys, adomen, whale eye,
Example MRI studies for animal models of cardiac, renal, gastroenterological and musculoskeletal diseases and biology.
A mouse tumor (MDA-MB-231 solid tumor xenograft marked with arrow) visualized using Dynamic Contrast Enhanced MRI with Magnevist (upper row) and a targeted (Transferrin-Liposome-Magnevist) nanocomplex (lower row). The targeted nanocomplex exhibited a stronger and heterogeneous signal enhancement.
Coronal MRI images of mouse brains and spinal cord
In vivo (upper row) and ex vivo (lower row) normal mouse brain images visualized using a high resolution T2 weighted fast spin-echo MRI sequence. This sequence is designed to detect Alzheimer's pathology (amyloid plaques) in the brains and spinal cords of transgenic mice, which become detectable by MRI at 6-8 months of disease progression.
Contact
Paul Wang, Ph.D.

pwang@howard.edu

Sub Cores
CCBB Core
Imaging Core
Proteomics Core
Outcome Center

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